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Can thyroid problems cause kidney disease? Because thyroid hormone has numerous effects on the kidney, heart, and vascular system, thyroid dysfunction can cause significant changes in renal and cardiovascular functions (1–3). In particular, hypothyroidism is known to be associated with reduced renal plasma flow (RPF) and low glomerular filtration rate (GFR). What happens if a goiter is left untreated? Untreated hypothyroidism can lead to a number of health problems: Goiter. Although generally not uncomfortable, a large goiter can affect your appearance and may interfere with swallowing or breathing. Heart problems. Are goiters dangerous? Your thyroid is a butterfly-shaped gland located at the base of your neck just below your Adam's apple. Although goiters are usually painless, a large goiter can cause a cough and make it difficult for you to swallow or breathe. The most common cause of goiters worldwide is a lack of iodine in the diet.
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